What type of Anaesthetic is desflurane?

Desflurane is a general inhalation anesthetic for inpatient and outpatient surgery in adults. Desflurane, or I-653, a a volatile anesthetic that is more rapidly cleared and less metabolized than previous inhaled anesthetics such as methoxyflurane, sevoflurane, enflurane, or isoflurane. 4,2,21.

What is the use of desflurane?

Desflurane belongs to the group of medicines known as general anesthetics. Inhaled desflurane is used to cause general anesthesia (loss of consciousness) before and during surgery in adults. It is also used as a maintenance anesthesia in adults and children after receiving other anesthetics before and during surgery.

How is desflurane administered?

Desflurane administration is via the inhalational route. It has a pungent odor, making it difficult to use for the induction of general anesthesia. It is used most commonly for maintenance of general anesthesia after induction with an IV or another inhalational agent.

What is desflurane made of?

Desflurane (1,2,2,2-tetrafluoroethyl difluoromethyl ether) is a highly fluorinated methyl ethyl ether used for maintenance of general anesthesia. Like halothane, enflurane, and isoflurane, it is a racemic mixture of (R) and (S) optical isomers (enantiomers).

How bad is desflurane for the environment?

Inhalational anaesthetic agents are chlorofluorocarbons, ‘greenhouse gases’ that have between 349 (sevoflurane) and 3714 (desflurane) times the global warming potential over a 20 year time horizon of carbon dioxide (isoflurane 1401), equivalent to driving a car 18 (sevoflurane) to ~350 miles (desflurane) per hour of

What is another name for desflurane?

SUPRANE (desflurane, USP) is a colorless, non-flammable, volatile liquid (below 22.8°C) for inhalation, 100% desflurane.

What color is desflurane?

5) Desflurane: Colour code – Sky blue MAC = 6 % Desflurane is the newest volatile agent, synthesised in 1993. It is expensive and needs a sophisticated vaporiser for administration.

Why is nitrous oxide used in anesthesia?

Nitrous oxide transfers across the alveolus rapidly because of its high lipid solubility. This leads to concentration of the remaining gases in the alveolus (volatile agent, oxygen, and nitrogen), increasing the driving pressure of volatile anaesthetic agent into the blood.

How much does desflurane cost?

How Tabing et al. 1 calculated the cost of desflurane and sevoflurane to be $13.20 and $0.63 per case, respectively, a more than 2,000% difference, is enigmatic.

What does desflurane smell like?

It is sweet smelling and minimally pungent, and hence well suited to inhalational inductions. Because of its complete fluorination, sevoflurane has a very low blood solubility (among commonly used volatile anesthetics, only desflurane has a lower solubility). It is approximately half as potent as isoflurane.

How much does a bottle of sevoflurane cost?

The cost for sevoflurane inhalation liquid 100% is around $84 for a supply of 250 milliliters, depending on the pharmacy you visit.

Inhalation Liquid.

QuantityPer unitPrice
250 milliliters$0.34 – $0.44$84.26 – $109.46
1500 (6 x 250 milliliters)$0.46$686.75 – $694.94

Why is desflurane heated?

Desflurane vaporizers are heated to 39 degrees C, which increases the vapor pressure in the sump to 1300mmHg, preventing the possibility of boiling in warm OR rooms. Providing an external heat source compensates for the significant heat loss associated with desflurane vaporization.

What is the most potent inhaled anesthetic?

C Inhaled Volatile Agents

Isoflurane appears to have the most potent effect, whereas desflurane also has the potential to cause the reverse effect and induce airway constriction.

Why is desflurane not used for induction?

Because of its low pungency and low risk of respiratory irritation, sevoflurane is currently the most popular anesthetic agent in North America for anesthesia induction by inhalation. Conversely, desflurane is avoided for induction because of its high pungency and high risk of respiratory irritation.

Which volatile agent requires heat to change from a liquid to a gas?

The heat energy required to convert one kilogram of a substance from liquid into gas form at a given temperature is called the latent heat of vapourisation. As a volatile anaesthetic drug evaporates the molecules with the highest kinetic energy leave the liquid state and take energy with them.

What does a vaporizer do anesthesia?

It works by controlling the vaporization of anesthetic agents from liquid, and then accurately controlling the concentration in which these are added to the fresh gas flow. The design of these devices takes account of varying: ambient temperature, fresh gas flow, and agent vapor pressure.

What mixture of gases are used in Anaesthesia?

The medical gases used in anaesthesia and intensive care are oxygen, nitrous oxide, medical air, entonox, carbon dioxide and heliox. Oxygen is one of the most widely used gases for life-support and respiratory therapy besides anaesthetic procedures.

What is a variable bypass vaporizer?

They’re called variable bypass vaporizers because of what is being done when the dial is turned. Turning the dial changes the amount of oxygen that flows through a bypass chamber where it doesn’t encounter the inhalant versus the ratio of gas that’s flowing down through the vaporizing chamber.

What is a vaporizer do?

Vaporizers heat the water and add steam to the air. Cool-mist humidifiers add a cool fine vapor. Both devices can help relieve skin and nasal dryness. Adding moisture to the air, whether using a cool or warm mist, may also help ease symptoms such as nasal and chest congestion, along with coughing.

How is general anesthesia defined?

General anesthesia is a combination of medications that put you in a sleep-like state before a surgery or other medical procedure. Under general anesthesia, you don’t feel pain because you’re completely unconscious. General anesthesia usually uses a combination of intravenous drugs and inhaled gasses (anesthetics).

Why does SVP increase with temperature?

As a liquid is heated, its SVP increases in a non-linear fashion (Fig. 1). At a certain temperature, the boiling point, liquid molecules can enter their vapour phase within the liquid, creating bubbles of saturated vapour that rise to the surface and break free. SVP increases non-linearly with temperature.